Mercedes-Benz E450 4matic MPG by year — every rating on record
The Mercedes-Benz E450 4matic has a combined EPA fuel economy rating for 9 model years, from 2019 to 2027. Across those years its best rated version returned 26 mpg (2021) and its thirstiest returned 23 mpg (2019). The EPA record holds 9 configurations for this nameplate, most recently a Midsize Cars.
Year-by-year EPA ratings
| Model year | Configurations | Best combined | Worst combined | Class rank that year | Drivetrains | Fuel | EPA class |
|---|---|---|---|---|---|---|---|
| 2019 | 1 | 23 mpg | 23 mpg | #111 of 127 (13th pct) | 4-Wheel Drive | Premium | Midsize Cars |
| 2020 | 1 | 23 mpg | 23 mpg | #102 of 124 (18th pct) | 4-Wheel Drive | Premium | Midsize Cars |
| 2021 | 1 | 26 mpg | 26 mpg | #76 of 116 (35th pct) | 4-Wheel Drive | Premium | Midsize Cars |
| 2022 | 1 | 25 mpg | 25 mpg | #88 of 121 (28th pct) | 4-Wheel Drive | Premium | Midsize Cars |
| 2023 | 1 | 26 mpg | 26 mpg | #74 of 117 (37th pct) | All-Wheel Drive | Premium | Midsize Cars |
| 2024 | 1 | 25 mpg | 25 mpg | #77 of 101 (24th pct) | All-Wheel Drive | Premium | Midsize Cars |
| 2025 | 1 | 25 mpg | 25 mpg | #65 of 86 (25th pct) | All-Wheel Drive | Premium | Midsize Cars |
| 2026 | 1 | 25 mpg | 25 mpg | #53 of 66 (20th pct) | All-Wheel Drive | Premium | Midsize Cars |
| 2027 | 1 | 25 mpg | 25 mpg | #11 of 12 (9th pct) | All-Wheel Drive | Premium | Midsize Cars |
Where it has stood in its class
Ranked against every other nameplate the EPA filed under the same class that year. The Mercedes-Benz E450 4matic placed highest in 2027 at #11 of 12, and lowest in 2019 at #111 of 127. It spent 0 of its 9 ranked years in the top half of its class.
Every configuration on record
All 9 configurations EPA lists for this nameplate, newest first.
| Year | Configuration | Engine detail | City | Highway | Combined | Gallons/yr | Barrels/yr | EPA fuel cost/yr | CO2 g/mi | GHG |
|---|---|---|---|---|---|---|---|---|---|---|
| 2027 | 3.0L 6-cyl All-Wheel Drive Automatic 9-spd Premium | SIDI; Mild Hybrid, supercharged, turbocharged, Hybrid, start-stop | 22 | 31 | 25 | 460.0 | 11.9 | $3,100 | 355 | 5/10 |
| 2026 | 3.0L 6-cyl All-Wheel Drive Automatic 9-spd Premium | SIDI; Mild Hybrid, supercharged, turbocharged, Hybrid, start-stop | 22 | 31 | 25 | 460.0 | 11.9 | $3,100 | 355 | 5/10 |
| 2025 | 3.0L 6-cyl All-Wheel Drive Automatic 9-spd Premium | SIDI; Mild Hybrid, supercharged, turbocharged, Hybrid, start-stop | 22 | 31 | 25 | 460.0 | 11.9 | $3,100 | 355 | 5/10 |
| 2024 | 3.0L 6-cyl All-Wheel Drive Automatic 9-spd Premium | SIDI; Mild Hybrid, supercharged, turbocharged, Hybrid, start-stop | 22 | 31 | 25 | 460.0 | 11.9 | $3,100 | 355 | 5/10 |
| 2023 | 3.0L 6-cyl All-Wheel Drive Automatic 9-spd Premium | SIDI; Mild Hybrid, turbocharged, Hybrid, start-stop | 23 | 31 | 26 | 442.3 | 11.4 | $3,000 | 343 | 5/10 |
| 2022 | 3.0L 6-cyl 4-Wheel Drive Automatic 9-spd Premium | SIDI; Mild Hybrid, turbocharged, Hybrid, start-stop | 23 | 30 | 25 | 460.0 | 11.9 | $3,100 | 348 | 5/10 |
| 2021 | 3.0L 6-cyl 4-Wheel Drive Automatic 9-spd Premium | SIDI; Mild Hybrid, turbocharged, Hybrid, start-stop | 23 | 30 | 26 | 442.3 | 11.4 | $3,000 | 349 | 5/10 |
| 2020 | 3.0L 6-cyl 4-Wheel Drive Automatic 9-spd Premium | SIDI, turbocharged, start-stop | 20 | 28 | 23 | 500.0 | 12.9 | $3,350 | 392 | 5/10 |
| 2019 | 3.0L 6-cyl 4-Wheel Drive Automatic 9-spd Premium | SIDI, turbocharged, start-stop | 20 | 28 | 23 | 500.0 | 12.9 | $3,350 | 392 | 5/10 |
How the rating has moved between model years
Comparing the best-rated configuration of each year. 2 of 4 year-over-year steps improved the top rating.
| Change | Best combined | Delta | Gallons a year at the newer rating |
|---|---|---|---|
| 2020 → 2021 | 23 → 26 mpg | +3 mpg | 442 gal |
| 2021 → 2022 | 26 → 25 mpg | -1 mpg | 460 gal |
| 2022 → 2023 | 25 → 26 mpg | +1 mpg | 442 gal |
| 2023 → 2024 | 26 → 25 mpg | -1 mpg | 460 gal |
What E450 4matic fuel costs over a year
At the EPA's 11,500 miles a year, the 2027 Mercedes-Benz E450 4matic burns 460 to 460 gallons depending on configuration. Below is what that costs at three pump prices, and how much more the thirstiest configuration costs than the most efficient one.
| Pump price | Most efficient | Thirstiest | Spread |
|---|---|---|---|
| $3.00/gal | $1,380 | $1,380 | $0 |
| $3.50/gal | $1,610 | $1,610 | $0 |
| $4.00/gal | $1,840 | $1,840 | $0 |
EPA’s own estimate for the 2027 model year is $3,100 to $3,100 a year in fuel, or $4,250 more than the average new vehicle over five years.
How it compares with other Midsize Cars
Across the 483 nameplates EPA classifies as Midsize Cars, the median best combined rating is 25 mpg. At 25 mpg the Mercedes-Benz E450 4matic is exactly at the median.
- All Midsize Cars rankings — every nameplate in the class, best to worst.
Other Mercedes-Benz nameplates
Every Mercedes-Benz model compared → — all nameplates ranked by best combined rating, with what each one costs a year.