Mercedes-Benz E350 MPG by year — every rating on record

The Mercedes-Benz E350 has a combined EPA fuel economy rating for 18 model years, from 2006 to 2027. Across those years its best rated version returned 28 mpg (2025) and its thirstiest returned 19 mpg (2007). The EPA record holds 24 configurations for this nameplate, most recently a Midsize Cars.

Year-by-year EPA ratings

Where it has stood in its class

Ranked against every other nameplate the EPA filed under the same class that year. The Mercedes-Benz E350 placed highest in 2027 at #7 of 12, and lowest in 2021 at #85 of 116. It spent 0 of its 18 ranked years in the top half of its class.

Every configuration on record

All 24 configurations EPA lists for this nameplate, newest first.

How the rating has moved between model years

Comparing the best-rated configuration of each year. 6 of 10 year-over-year steps improved the top rating.

What E350 fuel costs over a year

At the EPA's 11,500 miles a year, the 2027 Mercedes-Benz E350 burns 411 to 411 gallons depending on configuration. Below is what that costs at three pump prices, and how much more the thirstiest configuration costs than the most efficient one.

EPA’s own estimate for the 2027 model year is $2,750 to $2,750 a year in fuel, or $2,500 more than the average new vehicle over five years.

How it compares with other Midsize Cars

Across the 483 nameplates EPA classifies as Midsize Cars, the median best combined rating is 25 mpg. At 28 mpg the Mercedes-Benz E350 is 3 mpg better the median, which is worth about $173 a year at $3.50 a gallon.

• All Midsize Cars rankings — every nameplate in the class, best to worst.

Other Mercedes-Benz nameplates

Every Mercedes-Benz model compared → — all nameplates ranked by best combined rating, with what each one costs a year.