Mercedes-Benz E350 4matic MPG by year — every rating on record

The Mercedes-Benz E350 4matic has a combined EPA fuel economy rating for 19 model years, from 2006 to 2027. Across those years its best rated version returned 27 mpg (2024) and its thirstiest returned 18 mpg (2008). The EPA record holds 25 configurations for this nameplate, most recently a Midsize Cars.

In the EPA record this nameplate also appears as E350 4matic and E350 4Matic. The figures below cover every one of them.

Year-by-year EPA ratings

Where it has stood in its class

Ranked against every other nameplate the EPA filed under the same class that year. The Mercedes-Benz E350 4matic placed highest in 2027 at #8 of 12, and lowest in 2022 at #94 of 121. It spent 0 of its 19 ranked years in the top half of its class.

Every configuration on record

All 25 configurations EPA lists for this nameplate, newest first.

How the rating has moved between model years

Comparing the best-rated configuration of each year. 5 of 7 year-over-year steps improved the top rating.

What E350 4matic fuel costs over a year

At the EPA's 11,500 miles a year, the 2027 Mercedes-Benz E350 4matic burns 426 to 426 gallons depending on configuration. Below is what that costs at three pump prices, and how much more the thirstiest configuration costs than the most efficient one.

EPA’s own estimate for the 2027 model year is $2,850 to $2,850 a year in fuel, or $3,000 more than the average new vehicle over five years.

How it compares with other Midsize Cars

Across the 483 nameplates EPA classifies as Midsize Cars, the median best combined rating is 25 mpg. At 27 mpg the Mercedes-Benz E350 4matic is 2 mpg better the median, which is worth about $119 a year at $3.50 a gallon.

• All Midsize Cars rankings — every nameplate in the class, best to worst.

Other Mercedes-Benz nameplates

Every Mercedes-Benz model compared → — all nameplates ranked by best combined rating, with what each one costs a year.