Lexus RX 350 MPG by year — every rating on record

The Lexus RX 350 has a combined EPA fuel economy rating for 20 model years, from 2007 to 2026. Across those years its best rated version returned 25 mpg (2023) and its thirstiest returned 19 mpg (2007). The EPA record holds 49 configurations for this nameplate, most recently a Small Sport Utility Vehicle 2WD / Small Sport Utility Vehicle 4WD.

Year-by-year EPA ratings

Where it has stood in its class

Ranked against every other nameplate the EPA filed under the same class that year. The Lexus RX 350 placed highest in 2007 at #24 of 71, and lowest in 2025 at #69 of 82. It spent 6 of its 20 ranked years in the top half of its class.

Every configuration on record

All 49 configurations EPA lists for this nameplate, newest first.

How the rating has moved between model years

Comparing the best-rated configuration of each year. 3 of 3 year-over-year steps improved the top rating.

What RX 350 fuel costs over a year

At the EPA's 11,500 miles a year, the 2026 Lexus RX 350 burns 460 to 479 gallons depending on configuration. Below is what that costs at three pump prices, and how much more the thirstiest configuration costs than the most efficient one.

EPA’s own estimate for the 2026 model year is $3,100 to $3,250 a year in fuel, or $4,250 more than the average new vehicle over five years.

How it compares with other Small Sport Utility Vehicle 4WD

Across the 311 nameplates EPA classifies as Small Sport Utility Vehicle 4WD, the median best combined rating is 27 mpg. At 25 mpg the Lexus RX 350 is 2 mpg below the median, which is worth about $119 a year at $3.50 a gallon.

• All Small Sport Utility Vehicle 4WD rankings — every nameplate in the class, best to worst.

Other Lexus nameplates

Every Lexus model compared → — all nameplates ranked by best combined rating, with what each one costs a year.